منابع مشابه
FoxO1 breaks diabetic heart
The incidence of type 2 diabetes is increasing explosively around the world. Both hyperglycemia and insulin resistance can cause myocardial damages with coronary atherosclerosis in type 2 diabetes. In addition, some patients show cardiac functional disorder, characterized by diastolic dysfunction, without ischemia. In a large prospective study in the Framingham cohort, patients with diabetes sh...
متن کاملFOXO1 Differentially Regulates Both Normal and Diabetic Gingival Wound Healing
We have previously demonstrated that keratinocyte-specific forkhead box O1 (FOXO1) deletion interferes with keratinocyte migration in normal skin wounds. However it has an opposite effect in diabetic skin wounds, significantly improving the healing response. In addition we found that skin epithelium regulates connective tissue healing mediated by FOXO1, which is strongly associated with wound a...
متن کاملFOXO1 differentially regulates both normal and diabetic wound healing
Healing is delayed in diabetic wounds. We previously demonstrated that lineage-specific Foxo1 deletion in keratinocytes interfered with normal wound healing and keratinocyte migration. Surprisingly, the same deletion of Foxo1 in diabetic wounds had the opposite effect, significantly improving the healing response. In normal glucose media, forkhead box O1 (FOXO1) enhanced keratinocyte migration ...
متن کاملLoss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay
ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney disease (DKD) is unclear. Diabetic Timp3(-/-) mice showed increased albuminuria, increased membrane thickness and mesangial expansion. Microarray profiling uncovered a significant reduction of Foxo1 expression in diabetic Timp3(-/-) mice compared to WT, along with FoxO1 target genes involved in autopha...
متن کاملFoxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds
Re-epithelialization is an important part in mucosal wound healing. Surprisingly little is known about the impact of diabetes on the molecular events of mucosal healing. We examined the role of the transcription factor forkhead box O1 (Foxo1) in oral wounds of diabetic and normoglycemic mice with keratinocyte-specific Foxo1 deletion. Diabetic mucosal wounds had significantly delayed healing wit...
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ژورنال
عنوان ژورنال: Journal of Diabetes Investigation
سال: 2012
ISSN: 2040-1116
DOI: 10.1111/jdi.12022